Genome editing lets scientists rewrite DNA, the instruction manual inside every living cell, with a precision that was unthinkable a generation ago. Technologies such as CRISPR have made this almost ...

SVPV enables visualisation of predicted structural variant regions in paired-end whole genome sequencing alignments, and allows comparison of calls from differenct structural variant prediction ...

The success of a molecular dynamics simulation depends on the accuracy of the force field used to define the atomic interactions. It is challenging to train both classical and modern machine-learning ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. As molecular modeling gains ever more prominence in understanding cellular processes, ...

Retrospective Analysis of BRCA-Altered Uterine Sarcoma Treated With Poly(ADP-ribose) Polymerase Inhibitors Chondrosarcomas are rare cancers of cartilage with limited systemic therapy options. To ...

MEREDITH identified a broader range of treatment options (median 4) compared with MTB experts (median 2). These options included therapies on the basis of preclinical data and combination treatments, ...

With the release of more and more AlphaFold (Jumper et al., 2021) or RoseTTAFold (Baek et al., 2021) predicted structures and experimentally determined structures, it is important to be able to do ...

MDANSE is a Python package designed for analysing molecular dynamics (MD) trajectories. One of its functions is calculating the expected results of neutron scattering experiments. The results can be ...

In silico assessment of protein receptor interactions with small ligands is now part of the standard pipeline for drug discovery, and numerous tools and protocols have been developed for this purpose.

What does SARS-CoV-2, the virus that causes COVID-19, look like? This simple question does not have a simple answer. SARS-CoV-2 is very small, and seeing it requires specialized scientific techniques.